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Crystal structure of rsv two-domain integrase
Analyse Crystal structure of rsv two-domain integrase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1C1A
- Type
- protein
- Length
- 430 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rsv integrase
- EC
- 2.7.7.49
- UniProt
- P03354
- Pockets
- 6 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rsv integrase (EC 2.7.7.49) | protein | 221 | 34% helix, 27% strand | P03354 |
| B | Rsv integrase (EC 2.7.7.49) | protein | 209 | 35% helix, 26% strand | P03354 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 594 | 0.78 | 0.84 | 51 | empty |
| 2 | 606 | 0.76 | 0.82 | 56 | empty |
| 3 | 120 | 0.40 | 0.75 | 16 | empty |
| 4 | 76 | 0.35 | 0.76 | 14 | empty |
| 5 | 94 | 0.34 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1805 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 1C1A · Crystal structure of rsv two-domain integrase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03354
- Elsewhere: RCSB PDB 1C1A · PDBe 1C1A · UniProt P03354
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