UniProt P03354
integrase (P03354)
integrase (UniProt P03354), EC 2.7.7.-: 68 experimental structures on GenesisL1, 8 ligands bound, 20 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P03354
- Protein
- integrase
- EC
- 2.7.7.-
- Experimental structures
- 68
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 20 · 1 record with a druggable one
Structures
68 records of P03354 in the MolNFT archive: 68 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A5V | Asv integrase core domain with HIV-1 integrase inhibitor Y3 and mn cation | x-ray diffraction | A | — | — |
| 1A5V | Asv integrase core domain with HIV-1 integrase inhibitor Y3 and mn cation | x-ray diffraction | A | — | — |
| 1A5W | Asv integrase core domain with HIV-1 integrase inhibitor Y3 | x-ray diffraction | A | — | — |
| 1A5W | Asv integrase core domain with HIV-1 integrase inhibitor Y3 | x-ray diffraction | A | — | — |
| 1A5X | Asv integrase core domain with HIV-1 integrase inhibitor Y3 | x-ray diffraction | A | — | — |
| 1A5X | Asv integrase core domain with HIV-1 integrase inhibitor Y3 | x-ray diffraction | A | — | — |
| 1ASU | Avian sarcoma virus integrase catalytic core domain crystallized from 2% peg 400, 2M ammonium… | x-ray diffraction | A | — | — |
| 1ASU | Avian sarcoma virus integrase catalytic core domain crystallized from 2% peg 400, 2M ammonium… | x-ray diffraction | A | — | — |
| 1ASV | Avian sarcoma virus integrase catalytic core domain | x-ray diffraction | A | — | — |
| 1ASV | Avian sarcoma virus integrase catalytic core domain | x-ray diffraction | A | — | — |
| 1ASW | Avian sarcoma virus integrase catalytic core domain crystallized from 20% peg 4000, 10%… | x-ray diffraction | A | — | — |
| 1ASW | Avian sarcoma virus integrase catalytic core domain crystallized from 20% peg 4000, 10%… | x-ray diffraction | A | — | — |
| 1C0M | Crystal structure of rsv two-domain integrase | x-ray diffraction | A, B, C, D | — | — |
| 1C0M | Crystal structure of rsv two-domain integrase | x-ray diffraction | A, B, C, D | — | — |
| 1C1A | Crystal structure of rsv two-domain integrase | x-ray diffraction | A, B | — | — |
| 1C1A | Crystal structure of rsv two-domain integrase | x-ray diffraction | A, B | — | — |
| 1CXQ | Atomic resolution asv integrase core domain from ammonium sulfate | x-ray diffraction | A | — | — |
| 1CXQ | Atomic resolution asv integrase core domain from ammonium sulfate | x-ray diffraction | A | — | — |
| 1CXU | 1.42A resolution asv integrase core domain from citrate | x-ray diffraction | A | — | — |
| 1CXU | 1.42A resolution asv integrase core domain from citrate | x-ray diffraction | A | — | — |
| 1CZ9 | Atomic resolution asv integrase core domain (D64N) from citrate | x-ray diffraction | A | — | — |
| 1CZ9 | Atomic resolution asv integrase core domain (D64N) from citrate | x-ray diffraction | A | — | — |
| 1CZB | Atomic resolution asv integrase core domain from hepes | x-ray diffraction | A | — | — |
| 1CZB | Atomic resolution asv integrase core domain from hepes | x-ray diffraction | A | — | — |
| 1VSD | Asv integrase core domain with MG(II) cofactor and hepes ligand, high mg concentration form | x-ray diffraction | A | — | — |
| 1VSD | Asv integrase core domain with MG(II) cofactor and hepes ligand, high mg concentration form | x-ray diffraction | A | — | — |
| 1VSE | Asv integrase core domain with MG(II) cofactor and hepes ligand, low mg concentration form | x-ray diffraction | A | — | — |
| 1VSE | Asv integrase core domain with MG(II) cofactor and hepes ligand, low mg concentration form | x-ray diffraction | A | — | — |
| 1VSF | Asv integrase core domain with MN(II) cofactor and hepes ligand, high mg concentration form | x-ray diffraction | A | — | — |
| 1VSF | Asv integrase core domain with MN(II) cofactor and hepes ligand, high mg concentration form | x-ray diffraction | A | — | — |
| 1VSH | Asv integrase core domain with ZN(II) cofactors | x-ray diffraction | A | — | — |
| 1VSH | Asv integrase core domain with ZN(II) cofactors | x-ray diffraction | A | — | — |
| 1VSI | Asv integrase core domain with CA(II) cofactor | x-ray diffraction | A | — | — |
| 1VSI | Asv integrase core domain with CA(II) cofactor | x-ray diffraction | A | — | — |
| 1VSJ | Asv integrase core domain with CD(II) cofactors | x-ray diffraction | A | — | — |
| 1VSJ | Asv integrase core domain with CD(II) cofactors | x-ray diffraction | A | — | — |
| 1VSK | Asv integrase core domain D64N mutation in citrate buffer pH 6.0 | x-ray diffraction | A | — | — |
| 1VSK | Asv integrase core domain D64N mutation in citrate buffer pH 6.0 | x-ray diffraction | A | — | — |
| 1VSL | Asv integrase core domain D64N mutation with zinc cation | x-ray diffraction | A | — | — |
| 1VSL | Asv integrase core domain D64N mutation with zinc cation | x-ray diffraction | A | — | — |
| 1VSM | Asv integrase core domain in citrate buffer pH 5.0 | x-ray diffraction | A | — | — |
| 1VSM | Asv integrase core domain in citrate buffer pH 5.0 | x-ray diffraction | A | — | — |
| 3TIR | Pseudo-atomic model of the Rous Sarcoma Virus capsid hexamer | x-ray diffraction | A | — | — |
| 3TIR | Pseudo-atomic model of the rous sarcoma virus capsid hexamer | x-ray diffraction | A | — | — |
| 4FW1 | Crystal structure of two-domain RSV INTEGRASE covalently linked with DNA | x-ray diffraction | A, B | — | — |
| 4FW1 | Crystal structure of two-domain rsv integrase covalently linked with DNA | x-ray diffraction | A, B | — | — |
| 4FW2 | Crystal structure of RSV three-domain integrase with disordered N-terminal domain | x-ray diffraction | A, B | — | — |
| 4FW2 | Crystal structure of rsv three-domain integrase with disordered N- terminal domain | x-ray diffraction | A, B | — | — |
| 5EJK | Crystal structure of the Rous sarcoma virus intasome | x-ray diffraction | A, B, C, D, E, F, G, H | ZN, W | — |
| 5EJK | Crystal structure of the rous sarcoma virus intasome | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5KZ9 | Crystal structure of the Rous sarcoma virus matrix protein. | x-ray diffraction | A | — | — |
| 5KZ9 | Crystal structure of the rous sarcoma virus matrix protein. | x-ray diffraction | A | — | — |
| 5KZA | Crystal structure of the Rous sarcoma virus matrix protein (aa 2-102). Space group I41 | x-ray diffraction | A | NO3 | — |
| 5KZA | Crystal structure of the rous sarcoma virus matrix protein (aa 2-102). space group I41 | x-ray diffraction | A | NO3 | — |
| 5KZB | Crystal structure of the Rous sarcoma virus matrix protein (aa 2-102). Space group I4122 | x-ray diffraction | A | — | — |
| 5KZB | Crystal structure of the rous sarcoma virus matrix protein (aa 2-102). space group I4122 | x-ray diffraction | A | — | — |
| 6CCJ | NMR structure of the rous sarcoma virus matrix protein (M domain) | solution nmr | A | — | — |
| 6CE5 | NMR structure of the rous sarcoma virus matrix protein (M-domain) in the presence of myo-inositol… | solution nmr | A | — | — |
| 6CUS | HADDOCK structure of the Rous sarcoma virus matrix protein (M-domain) in complex with myo-inositol… | solution nmr | A | IHP | — |
| 6CUS | Haddock structure of the rous sarcoma virus matrix protein (M-domain) in complex with myo-inositol… | solution nmr | A | IHP | — |
8 records more on the page itself.
Ligands
- ZN · Zinc ion · in 5 records
- ZZX · (6S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N, 6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1', 2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide · in 4 records
- MG · Magnesium ion · in 3 records
- FGV · (1R,2S,3r,4R,5S,6s)-2,4,6-trihydroxycyclohexane-1,3,5-triyl tris[dihydrogen (phosphate)] · in 2 records
- I3P · D-myo-inositol-1,4,5-triphosphate · in 2 records
- IHP · Inositol hexakisphosphate · in 2 records
- NO3 · Nitrate ion · in 2 records
- W · Tungsten ion · in 1 record
Elsewhere
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