Research workbench
Crystal structure of rsv two-domain integrase
Analyse Crystal structure of rsv two-domain integrase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1C0M
- Type
- protein
- Length
- 875 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (integrase)
- EC
- 2.7.7.49
- UniProt
- P03354
- Pockets
- 11 · best druggability 0.78
Structure
x-ray diffraction · 3 distinct chains · 36% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (integrase) (EC 2.7.7.49) | protein | 221 | 35% helix, 27% strand | P03354 |
| B, D | Protein (integrase) (EC 2.7.7.49) | protein | 216 | 38% helix, 27% strand | P03354 |
| C | Protein (integrase) (EC 2.7.7.49) | protein | 222 | 35% helix, 27% strand | P03354 |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1049 | 0.78 | 0.80 | 72 | empty |
| 2 | 582 | 0.77 | 0.83 | 60 | empty |
| 3 | 550 | 0.73 | 0.81 | 46 | empty |
| 4 | 589 | 0.70 | 0.79 | 50 | empty |
| 5 | 125 | 0.47 | 0.78 | 20 | empty |
Interfaces
4 interfaces between chains.
- A–B · 1703 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 1662 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 237 Ų buried · 3 hydrogen bonds · protein-protein
- B–D · 109 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 1C0M · Crystal structure of rsv two-domain integrase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03354
- Elsewhere: RCSB PDB 1C0M · PDBe 1C0M · UniProt P03354
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.