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Solution structure of CR2 scr 1-2 in its complex with C3D by X-ray scattering

Analyse Solution structure of CR2 scr 1-2 in its complex with C3D by X-ray scattering in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1W2S
Type
protein
Length
449 residues
Chains
2
Method
solution scattering
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Complement C3 precursor; Complement receptor type 2 precursor,
UniProt
P01024, P20023
Pockets
1 · best druggability 0.27

Structure

solution scattering · 2 distinct chains · 0% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AComplement C3 precursorprotein3070% helix, 0% strandP01024
BComplement receptor type 2 precursor,protein1420% helix, 0% strandP20023

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1500.270.7214empty

Interfaces

1 interface between chains.

  • A–B · 199 Ų buried · 0 hydrogen bonds · protein-protein

Compared structures

  • 1W2S · Solution structure of CR2 SCR 1-2 in its complex with C3d by X-ray scattering · the same entry in another collection · chain A against A, TM-score 1.00
  • P01024 · AlphaFold monomer V2.0 prediction for complement C3 (P01024) · a predicted model of the same protein · chain A against A, TM-score 0.90
  • P20023 · AlphaFold monomer V2.0 prediction for complement receptor type 2 (P20023) · a predicted model of the same protein · chain B against A, TM-score 0.52

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