Research workbench
The crystal structure of the minimal functional domain of the microtubule destabilizer KIF2C complexed with mg-ADP
Analyse The crystal structure of the minimal functional domain of the microtubule… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1V8J
- Type
- protein
- Length
- 337 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kinesin-like protein KIF2C
- UniProt
- Q922S8
- Ligands
- ADP, MG
- Pockets
- 4 · best druggability 0.54
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kinesin-like protein KIF2C | protein | 337 | 36% helix, 27% strand | Q922S8 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 179 | 0.54 | 0.79 | 30 | empty |
| 2 | 180 | 0.52 | 0.78 | 24 | empty |
| 3 | 155 | 0.49 | 0.77 | 21 | empty |
| 4 | 144 | 0.46 | 0.77 | 38 | MG, ADP |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1V8J · The Crystal Structure of the Minimal Functional Domain of the Microtubule Destabilizer… · the same entry in another collection · chain A against A, TM-score 1.00
- Q922S8 · AlphaFold monomer V2.0 prediction for kinesin-like protein KIF2C (Q922S8) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q922S8
- Elsewhere: RCSB PDB 1V8J · PDBe 1V8J · UniProt Q922S8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.