Research workbench
Heterotrimeric complex of PHOSDUCIN/TRANSDUCIN beta-gamma
Analyse Heterotrimeric complex of PHOSDUCIN/TRANSDUCIN beta-gamma in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1A0R
- Type
- protein
- Length
- 592 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transducin (beta subunit); Transducin (gamma subunit); Phosducin
- UniProt
- P04901, P02698, P19632
- Ligands
- ACE, FAR
- Pockets
- 6 · best druggability 0.79
Structure
x-ray diffraction · 3 distinct chains · 25% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Transducin (beta subunit) | protein | 339 | 9% helix, 46% strand | P04901 |
| G | Transducin (gamma subunit) | protein | 65 | 60% helix, 0% strand | P02698 |
| P | Phosducin | protein | 188 | 43% helix, 15% strand | P19632 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 579 | 0.79 | 0.85 | 51 | empty |
| 2 | 490 | 0.70 | 0.80 | 61 | FAR |
| 3 | 341 | 0.63 | 0.79 | 39 | empty |
| 4 | 97 | 0.56 | 0.85 | 16 | empty |
| 5 | 117 | 0.47 | 0.79 | 29 | empty |
Interfaces
3 interfaces between chains.
- B–G · 2602 Ų buried · 23 hydrogen bonds · protein-protein
- B–P · 2223 Ų buried · 42 hydrogen bonds · protein-protein
- G–P · 28 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1A0R · Heterotrimeric complex of PHOSDUCIN/TRANSDUCIN beta-gamma · the same entry in another collection · chain B against B, TM-score 1.00
- P19632 · AlphaFold monomer V2.0 prediction for phosducin (P19632) · a predicted model of the same protein · chain P against A, TM-score 0.97
- P02698 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(T) subunit… · a predicted model of the same protein · chain G against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04901
- Every structure of UniProt P02698
- Every structure of UniProt P19632
- Elsewhere: RCSB PDB 1A0R · PDBe 1A0R · UniProt P04901 · UniProt P02698 · UniProt P19632
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