Research workbench
The crystal structure of beta-catenin armadillo repeat complexed with a phosphorylated apc 20MER repeat.
Analyse The crystal structure of beta-catenin armadillo repeat complexed with a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1V18
- Type
- protein
- Length
- 547 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-catenin; Adenomatous polyposis COLI
- UniProt
- Q02248, P25054
- Pockets
- 3 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-catenin | protein | 507 | 74% helix, 0% strand | Q02248 |
| B | Adenomatous polyposis COLI | protein | 40 | 13% helix, 0% strand | P25054 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 502 | 0.65 | 0.77 | 51 | empty |
| 2 | 238 | 0.52 | 0.76 | 25 | empty |
| 3 | 50 | 0.30 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 2119 Ų buried · 41 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (phosphorylation).
Compared structures
- 1V18 · The crystal structure of beta-catenin armadillo repeat complexed with a phosphorylated… · the same entry in another collection · chain A against A, TM-score 1.00
- Q02248 · AlphaFold monomer V2.0 prediction for catenin beta-1 (Q02248) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02248
- Every structure of UniProt P25054
- Elsewhere: RCSB PDB 1V18 · PDBe 1V18 · UniProt Q02248 · UniProt P25054
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