Research workbench
X-ray structure of acetylcholine binding protein (achbp) in complex with carbamylcholine
Analyse X-ray structure of acetylcholine binding protein (achbp) in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1UV6
- Type
- protein
- Length
- 2,050 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acetylcholine-binding protein
- UniProt
- P58154
- Ligands
- CCE
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 8% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J | Acetylcholine-binding protein | protein | 205 | 8% helix, 47% strand | P58154 |
Ligands and binding sites
- CCE · 2-[(aminocarbonyl)oxy]-N,N,N-trimethylethanaminium · ligand · 3 copies · chains C, D, E, F, J
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1185 | 0.84 | 0.85 | 114 | empty |
| 2 | 617 | 0.81 | 0.86 | 71 | empty |
| 3 | 684 | 0.80 | 0.84 | 56 | empty |
| 4 | 521 | 0.79 | 0.86 | 57 | empty |
| 5 | 388 | 0.73 | 0.84 | 48 | empty |
Interfaces
21 interfaces between chains.
- C–D · 1454 Ų buried · 21 hydrogen bonds · protein-protein
- H–I · 1450 Ų buried · 16 hydrogen bonds · protein-protein
- D–E · 1439 Ų buried · 19 hydrogen bonds · protein-protein
- F–J · 1429 Ų buried · 17 hydrogen bonds · protein-protein
- I–J · 1401 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 20 disulfide (disulfide).
Compared structures
- 1UV6 · X-ray structure of acetylcholine binding protein (AChBP) in complex with carbamylcholine · the same entry in another collection · chain J against J, TM-score 1.00
- P58154 · AlphaFold monomer V2.0 prediction for acetylcholine-binding protein (P58154) · a predicted model of the same protein · chain J against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P58154
- Elsewhere: RCSB PDB 1UV6 · PDBe 1UV6 · UniProt P58154
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.