Research workbench
Clathrin terminal domain complexed with tlpwdlwtt
Analyse Clathrin terminal domain complexed with tlpwdlwtt in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1UTC
- Type
- protein
- Length
- 719 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Clathrin heavy chain; Amphiphysin
- UniProt
- P49951, P49418
- Pockets
- 10 · best druggability 0.88
Structure
x-ray diffraction · 3 distinct chains · 8% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Clathrin heavy chain | protein | 352 | 8% helix, 51% strand | P49951 |
| B | Clathrin heavy chain | protein | 353 | 7% helix, 51% strand | P49951 |
| P, Q | Amphiphysin | protein | 7 | 43% helix, 0% strand | P49418 |
Pockets
10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1174 | 0.88 | 0.89 | 158 | empty |
| 2 | 185 | 0.63 | 0.84 | 33 | empty |
| 3 | 79 | 0.45 | 0.81 | 17 | empty |
| 4 | 54 | 0.43 | 0.82 | 12 | empty |
| 5 | 77 | 0.41 | 0.79 | 16 | empty |
Interfaces
5 interfaces between chains.
- A–B · 933 Ų buried · 11 hydrogen bonds · protein-protein
- A–P · 472 Ų buried · 7 hydrogen bonds · protein-protein
- B–Q · 462 Ų buried · 7 hydrogen bonds · protein-protein
- B–P · 307 Ų buried · 4 hydrogen bonds · protein-protein
- A–Q · 282 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 1UTC · Clathrin terminal domain complexed with TLPWDLWTT · the same entry in another collection · chain Q against Q, TM-score 1.00
- P49951 · AlphaFold monomer V2.0 prediction for clathrin heavy chain 1 (P49951) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P49418 · AlphaFold monomer V2.0 prediction for amphiphysin (P49418) · a predicted model of the same protein · chain Q against A, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49951
- Every structure of UniProt P49418
- Elsewhere: RCSB PDB 1UTC · PDBe 1UTC · UniProt P49951 · UniProt P49418
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