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The structure of the complex between AHA1 and HSP90

Analyse The structure of the complex between AHA1 and HSP90 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1USV
Type: protein
Length: 1,568 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heat shock protein HSP82; AHA1
UniProt: P02829, Q12449
Pockets: 20 · best druggability 0.69

Structure

x-ray diffraction · 8 distinct chains · 34% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heat shock protein HSP82	protein	251	37% helix, 22% strand	P02829
B	AHA1	protein	143	27% helix, 36% strand	Q12449
C	Heat shock protein HSP82	protein	247	38% helix, 22% strand	P02829
D	AHA1	protein	142	26% helix, 36% strand	Q12449
E	Heat shock protein HSP82	protein	251	36% helix, 20% strand	P02829
F	AHA1	protein	145	26% helix, 33% strand	Q12449
G	Heat shock protein HSP82	protein	248	38% helix, 23% strand	P02829
H	AHA1	protein	141	32% helix, 38% strand	Q12449

Pockets

20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	779	0.69	0.76	81	empty
2	357	0.64	0.79	47	empty
3	355	0.62	0.78	50	empty
4	203	0.56	0.79	29	empty
5	358	0.54	0.73	39	empty

Interfaces

10 interfaces between chains.

C–D · 844 Å² buried · 12 hydrogen bonds · protein-protein
G–H · 824 Å² buried · 11 hydrogen bonds · protein-protein
E–F · 791 Å² buried · 11 hydrogen bonds · protein-protein
A–B · 789 Å² buried · 12 hydrogen bonds · protein-protein
A–C · 322 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

1USV · The Structure of the complex between Aha1 and HSP90 · the same entry in another collection · chain H against H, TM-score 1.00
Q12449 · AlphaFold monomer V2.0 prediction for HSP90 co-chaperone AHA1 (Q12449) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02829
Every structure of UniProt Q12449
Elsewhere: RCSB PDB 1USV · PDBe 1USV · UniProt P02829 · UniProt Q12449

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