UniProt Q12449
Hsp90 co-chaperone AHA1 (Q12449)
Hsp90 co-chaperone AHA1 (UniProt Q12449): 12 experimental structures and 1 predicted model on GenesisL1, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q12449
- Protein
- Hsp90 co-chaperone AHA1
- Experimental structures
- 12
- Predicted models
- 1
- Pockets
- 26 · 3 records with a druggable one
Structures
13 records of Q12449 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1USU | The Structure of the complex between Aha1 and HSP90 | x-ray diffraction | B | — | — |
| 1USU | The structure of the complex between AHA1 and HSP90 | x-ray diffraction | B | — | — |
| 1USV | The Structure of the complex between Aha1 and HSP90 | x-ray diffraction | B, D, F, H | — | — |
| 1USV | The structure of the complex between AHA1 and HSP90 | x-ray diffraction | B, D, F, H | — | — |
| 6XLD | Full-length Hsc82 in complex with Aha1 CTD in the presence of AMPPNP | electron microscopy | C | — | 5 (best 0.70) |
| 6XLD | Full-length HSC82 in complex with AHA1 ctd in the presence of amppnp | electron microscopy | C | — | — |
| 6XLE | Full-length HSC82 in complex with two AHA1 ctd in the presence of AMP- pnp | electron microscopy | C, D | — | — |
| 6XLF | Full-length Hsc82 in complex with Aha1 in the presence of AMP-PNP | electron microscopy | C, D | — | 10 (best 0.76) |
| 6XLF | Full-length HSC82 in complex with AHA1 in the presence of AMP-pnp | electron microscopy | C, D | — | — |
| 6XLG | Full-length HSC82 in complex with two AHA1 ctd in the presence of atpgammas | electron microscopy | C, D | — | — |
| 6XLH | Asymmetric hydrolysis state of Hsc82 in complex with Aha1 bound with ADP and ATPgammaS | electron microscopy | C, D | — | 11 (best 0.73) |
| 6XLH | Asymmetric hydrolysis state of HSC82 in complex with AHA1 bound with ADP and atpgammas | electron microscopy | C, D | — | — |
| Q12449 | AlphaFold monomer V2.0 prediction for HSP90 co-chaperone AHA1 (Q12449) | predicted | A | — | — |
Experiment against prediction
- 6XLD chain C against the predicted model Q12449: TM-score 0.98, RMSD 0.59 Å
- 6XLD chain C against the predicted model Q12449: TM-score 0.98, RMSD 0.59 Å
- 1USV chain B against the predicted model Q12449: TM-score 0.98, RMSD 0.79 Å
- 1USV chain B against the predicted model Q12449: TM-score 0.98, RMSD 0.79 Å
- 1USU chain B against the predicted model Q12449: TM-score 0.98, RMSD 0.70 Å
- 1USU chain B against the predicted model Q12449: TM-score 0.98, RMSD 0.70 Å
- 1USV chain H against the predicted model Q12449: TM-score 0.98, RMSD 0.73 Å
- 1USV chain H against the predicted model Q12449: TM-score 0.98, RMSD 0.73 Å
- 1USV chain D against the predicted model Q12449: TM-score 0.98, RMSD 0.77 Å
- 1USV chain D against the predicted model Q12449: TM-score 0.98, RMSD 0.77 Å
Elsewhere
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