Research workbench
L-leucine-binding protein with leucine bound
Analyse L-leucine-binding protein with leucine bound in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1USK
- Type
- protein
- Length
- 1,380 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leucine-specific binding protein
- UniProt
- P04816
- Ligands
- LEU
- Pockets
- 16 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Leucine-specific binding protein | protein | 345 | 48% helix, 20% strand | P04816 |
Ligands and binding sites
- LEU · Leucine · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 474 | 0.73 | 0.83 | 47 | empty |
| 2 | 533 | 0.72 | 0.81 | 65 | empty |
| 3 | 97 | 0.53 | 0.83 | 26 | empty |
| 4 | 140 | 0.51 | 0.79 | 25 | empty |
| 5 | 154 | 0.48 | 0.77 | 27 | empty |
Interfaces
3 interfaces between chains.
- B–C · 889 Ų buried · 17 hydrogen bonds · protein-protein
- B–D · 191 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 139 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04816
- Elsewhere: RCSB PDB 1USK · PDBe 1USK · UniProt P04816
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