Research workbench
U1A MUTANT/RNA complex + glycerol
Analyse U1A MUTANT/RNA complex + glycerol in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1URN
- Type
- protein + RNA
- Length
- 344 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA (5'- R(*AP*AP*UP*CP*CP*AP*UP*UP*GP*CP*AP*CP*UP*CP*CP*GP*G P*AP*UP*UP*U)- 3'); Protein…
- UniProt
- P09012
- Ligands
- CL
- Pockets
- 6 · best druggability 0.45
Structure
x-ray diffraction · 4 distinct chains · 32% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| P | RNA (5'- R(*AP*AP*UP*CP*CP*AP*UP*UP*GP*CP*AP*CP*UP*CP*CP*GP*G P*AP*UP*UP*U)- 3') | rna | 17 | — | — |
| Q | RNA (5'- R(*AP*AP*UP*CP*CP*AP*UP*UP*GP*CP*AP*CP*UP*CP*CP*GP*G P*AP*UP*UP*U)- 3') | rna | 21 | — | — |
| R | RNA (5'- R(*AP*AP*UP*CP*CP*AP*UP*UP*GP*CP*AP*CP*UP*CP*CP*GP*G P*AP*UP*UP*U)- 3') | rna | 18 | — | — |
| A, B, C | Protein (U1A) | protein | 96 | 32% helix, 25% strand | P09012 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 127 | 0.45 | 0.77 | 22 | GOL |
| 2 | 184 | 0.45 | 0.75 | 26 | empty |
| 3 | 109 | 0.45 | 0.78 | 18 | GOL |
| 4 | 127 | 0.44 | 0.77 | 19 | empty |
| 5 | 122 | 0.41 | 0.76 | 21 | empty |
Interfaces
8 interfaces between chains.
- Q–B · 930 Ų buried · 32 hydrogen bonds · protein-nucleic
- R–C · 897 Ų buried · 31 hydrogen bonds · protein-nucleic
- P–A · 890 Ų buried · 31 hydrogen bonds · protein-nucleic
- A–C · 594 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 544 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 1URN · U1A MUTANT/RNA complex + glycerol · the same entry in another collection · chain P against P, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09012
- Elsewhere: RCSB PDB 1URN · PDBe 1URN · UniProt P09012
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.