Research workbench
Crystal structure of the E7_C/IM7_C complex; a computationally designed interface between the colicin E7 DNase and the IM7 immunity protein
Analyse Crystal structure of the E7_C/IM7_C complex; a computationally designed… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1UJZ
- Type
- protein
- Length
- 214 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Designed colicin E7 immunity protein; Designed colicin E7 DNase
- EC
- 3.1.-.-
- UniProt
- Q03708, Q47112
- Pockets
- 3 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Designed colicin E7 immunity protein | protein | 87 | 57% helix, 2% strand | Q03708 |
| B | Designed colicin E7 DNase (EC 3.1.-.-) | protein | 127 | 39% helix, 17% strand | Q47112 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 145 | 0.48 | 0.77 | 22 | empty |
| 2 | 108 | 0.37 | 0.75 | 19 | empty |
| 3 | 60 | 0.27 | 0.73 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 824 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 1UJZ · Crystal structure of the E7_C/Im7_C complex; a computationally designed interface between… · the same entry in another collection · chain A against A, TM-score 1.00
- Q03708 · AlphaFold monomer V2.0 prediction for colicin-E7 immunity protein (Q03708) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q47112 · AlphaFold monomer V2.0 prediction for colicin-E7 (Q47112) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03708
- Every structure of UniProt Q47112
- Elsewhere: RCSB PDB 1UJZ · PDBe 1UJZ · UniProt Q03708 · UniProt Q47112
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