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Crystal structure of tryptophan synthase a-subunit from thermus thermophilus HB8

Analyse Crystal structure of tryptophan synthase a-subunit from thermus thermophilus HB8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1UJP
Type: protein
Length: 243 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tryptophan synthase alpha chain
EC: 4.2.1.20
UniProt: P16608
Pockets: 1 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tryptophan synthase alpha chain (EC 4.2.1.20)	protein	243	51% helix, 15% strand	P16608

Ligands and binding sites

CIT · Citric acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	224	0.62	0.82	31	CIT

Compared structures

1UJP · Crystal Structure of Tryptophan Synthase A-Subunit From Thermus thermophilus HB8 · the same entry in another collection · chain A against A, TM-score 1.00
P16608 · AlphaFold monomer V2.0 prediction for tryptophan synthase alpha chain (P16608) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P16608
Elsewhere: RCSB PDB 1UJP · PDBe 1UJP · UniProt P16608

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