Research workbench
Hypothetical extein protein of PH1602 from pyrococcus horikoshii
Analyse Hypothetical extein protein of PH1602 from pyrococcus horikoshii in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1UC2
- Type
- protein
- Length
- 960 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypothetical protein PH1602
- UniProt
- O59245
- Ligands
- GLC, FRU, SO4
- Pockets
- 6 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Hypothetical protein PH1602 | protein | 480 | 37% helix, 24% strand | O59245 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A, B
- FRU · beta-D-fructofuranose · sugar · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 9 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 939 | 0.77 | 0.80 | 71 | SO4 |
| 2 | 1188 | 0.76 | 0.79 | 97 | SO4 |
| 3 | 172 | 0.64 | 0.85 | 26 | empty |
| 4 | 51 | 0.28 | 0.75 | 12 | empty |
| 5 | 65 | 0.27 | 0.72 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1337 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 1UC2 · Hypothetical Extein Protein of PH1602 from Pyrococcus horikoshii · the same entry in another collection · chain A against A, TM-score 1.00
- O59245 · AlphaFold monomer V2.0 prediction for RNA-splicing ligase rtcb (O59245) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O59245
- Elsewhere: RCSB PDB 1UC2 · PDBe 1UC2 · UniProt O59245
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