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Crystal structure of the zap-70 kinase domain in complex with staurosporine

Analyse Crystal structure of the zap-70 kinase domain in complex with staurosporine in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1U59
Type: protein
Length: 282 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein kinase zap-70
EC: 2.7.1.112
UniProt: P43403
Ligands: STU
Pockets: 1 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein kinase zap-70 (EC 2.7.1.112)	protein	282	38% helix, 21% strand	P43403

Ligands and binding sites

STU · Staurosporine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	506	0.66	0.78	53	STU

Compared structures

1U59 · Crystal Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine · the same entry in another collection · chain A against A, TM-score 1.00
P43403 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase zap-70 (P43403) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43403
Elsewhere: RCSB PDB 1U59 · PDBe 1U59 · UniProt P43403

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