Research workbench
Src family kinase hck SH3 domain
Analyse Src family kinase hck SH3 domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1BU1
- Type
- protein
- Length
- 339 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (hemopoietic cell kinase)
- EC
- 2.7.1.112
- UniProt
- P08631
- Pockets
- 4 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, E | Protein (hemopoietic cell kinase) (EC 2.7.1.112) | protein | 57 | 5% helix, 49% strand | P08631 |
| C, D, F | Protein (hemopoietic cell kinase) (EC 2.7.1.112) | protein | 56 | 5% helix, 48% strand | P08631 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 290 | 0.58 | 0.77 | 27 | empty |
| 2 | 138 | 0.42 | 0.75 | 18 | empty |
| 3 | 86 | 0.32 | 0.73 | 20 | empty |
| 4 | 57 | 0.30 | 0.75 | 13 | empty |
Interfaces
7 interfaces between chains.
- A–B · 503 Ų buried · 4 hydrogen bonds · protein-protein
- C–E · 437 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 333 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 297 Ų buried · 4 hydrogen bonds · protein-protein
- A–F · 219 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08631
- Elsewhere: RCSB PDB 1BU1 · PDBe 1BU1 · UniProt P08631
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