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Crystal structure of UP1 complexed with D(TTAGGGTTAG(DI)G); a human telomeric repeat containing inosine
Analyse Crystal structure of UP1 complexed with D(TTAGGGTTAG(DI)G); a human telomeric… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1U1O
- Type
- protein + DNA
- Length
- 194 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*GP*(OIP)*G)-3'; Heterogeneous nuclear ribonucleoprotein A1
- UniProt
- P09651
- Pockets
- 1 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 28% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | 5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*GP*(OIP)*G)-3' | dna | 11 | — | — |
| A | Heterogeneous nuclear ribonucleoprotein A1 | protein | 183 | 28% helix, 34% strand | P09651 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 229 | 0.58 | 0.79 | 35 | empty |
Interfaces
1 interface between chains.
- B–A · 802 Ų buried · 24 hydrogen bonds · protein-nucleic
Compared structures
- 1U1O · Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(DI)G); A Human Telomeric Repeat… · the same entry in another collection · chain B against B, TM-score 1.00
- P09651 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoprotein A1 (P09651) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09651
- Elsewhere: RCSB PDB 1U1O · PDBe 1U1O · UniProt P09651
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