Research workbench
Crystal structure of beta nerve growth factor at 2.5 a resolution in C2 space group with zn ions bound
Analyse Crystal structure of beta nerve growth factor at 2.5 a resolution in C2 space… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1BTG
- Type
- protein
- Length
- 326 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta nerve growth factor
- UniProt
- P01139
- Ligands
- ZN
- Pockets
- 3 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 0% helix, 59% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta nerve growth factor | protein | 108 | 0% helix, 60% strand | P01139 |
| B, C | Beta nerve growth factor | protein | 109 | 0% helix, 57% strand | P01139 |
Ligands and binding sites
- ZN · Zinc ion · metal · 3 copies · chains B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 306 | 0.72 | 0.85 | 40 | empty |
| 2 | 280 | 0.54 | 0.76 | 42 | empty |
| 3 | 173 | 0.42 | 0.73 | 20 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1283 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 249 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 218 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 9 disulfide (disulfide).
Compared structures
- 1BTG · Crystal structure of beta nerve growth factor at 2.5 a resolution in C2 space group with… · the same entry in another collection · chain A against A, TM-score 1.00
- P01139 · AlphaFold monomer V2.0 prediction for beta-nerve growth factor (P01139) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01139
- Elsewhere: RCSB PDB 1BTG · PDBe 1BTG · UniProt P01139
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