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Crystal structure of the GLUR5 ligand binding core in complex with glutamate at 2.1 ångström resolution

Analyse Crystal structure of the GLUR5 ligand binding core in complex with glutamate at… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1TXF
Type: protein
Length: 248 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutamate receptor, ionotropic kainate 1
UniProt: P22756
Ligands: GLU
Pockets: 2 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutamate receptor, ionotropic kainate 1	protein	248	40% helix, 22% strand	P22756

Ligands and binding sites

GLU · Glutamic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.72	0.97	20	GLU
2	98	0.40	0.77	21	empty

Compared structures

1TXF · Crystal structure of the GLUR5 ligand binding core in complex with glutamate at 2.1… · the same entry in another collection · chain A against A, TM-score 1.00
P22756 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, kainate 1 (P22756) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22756
Elsewhere: RCSB PDB 1TXF · PDBe 1TXF · UniProt P22756

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