Research workbench
Crystal structure of chicken liver basic fatty acid binding protein (bile acid binding protein) complexed with cholic acid
Analyse Crystal structure of chicken liver basic fatty acid binding protein (bile acid… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1TW4
- Type
- protein
- Length
- 250 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fatty acid-binding protein
- UniProt
- P80226
- Ligands
- CHD
- Pockets
- 3 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 59% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Fatty acid-binding protein | protein | 125 | 11% helix, 59% strand | P80226 |
Ligands and binding sites
- CHD · Cholic acid · ligand · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 712 | 0.83 | 0.86 | 46 | CHD |
| 2 | 843 | 0.83 | 0.85 | 63 | CHD |
| 3 | 214 | 0.47 | 0.74 | 35 | empty |
Interfaces
1 interface between chains.
- A–B · 268 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 1TW4 · Crystal Structure of Chicken Liver Basic Fatty Acid Binding Protein (Bile Acid Binding… · the same entry in another collection · chain A against A, TM-score 1.00
- P80226 · AlphaFold monomer V2.0 prediction for fatty acid-binding protein, liver (P80226) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P80226
- Elsewhere: RCSB PDB 1TW4 · PDBe 1TW4 · UniProt P80226
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