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Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand

Analyse Crystal structure of human adipocyte fatty acid binding protein in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1TOW
Type: protein
Length: 131 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fatty acid-binding protein, adipocyte
UniProt: P15090
Ligands: CRZ
Pockets: 1 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 13% helix, 58% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fatty acid-binding protein, adipocyte	protein	131	13% helix, 58% strand	P15090

Ligands and binding sites

CRZ · 4-(9H-carbazol-9-yl)butanoic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	279	0.84	0.95	34	CRZ

Compared structures

1TOW · Crystal structure of human adipocyte fatty acid binding protein in complex with a… · the same entry in another collection · chain A against A, TM-score 1.00
P15090 · AlphaFold monomer V2.0 prediction for fatty acid-binding protein, adipocyte (P15090) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P15090
Elsewhere: RCSB PDB 1TOW · PDBe 1TOW · UniProt P15090

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