Research workbench

Structures of the apo and calcium troponin-C regulatory domains: the muscle contraction switch

Analyse Structures of the apo and calcium troponin-C regulatory domains: the muscle… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1TNQ
Type: protein
Length: 90 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Troponin-C
UniProt: P02588
Ligands: CA
Pockets: 1 · best druggability 0.50

Structure

solution nmr · 1 distinct chain · 60% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Troponin-C	protein	90	60% helix, 4% strand	P02588

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	109	0.50	0.80	14	empty

Compared structures

1TNQ · Structures of the apo and calcium troponin-C regulatory domains: the muscle contraction… · the same entry in another collection · chain A against A, TM-score 1.00
P02588 · AlphaFold monomer V2.0 prediction for troponin C, skeletal muscle (P02588) · a predicted model of the same protein · chain A against A, TM-score 0.74

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02588
Elsewhere: RCSB PDB 1TNQ · PDBe 1TNQ · UniProt P02588

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