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Structure of otubain-2

Analyse Structure of otubain-2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1TFF
Type: protein
Length: 221 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin thiolesterase protein OTUB2
EC: 3.4.-.-
UniProt: Q96DC9
Pockets: 3 · best druggability 0.49

Structure

x-ray diffraction · 1 distinct chain · 58% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ubiquitin thiolesterase protein OTUB2 (EC 3.4.-.-)	protein	221	58% helix, 12% strand	Q96DC9

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	73	0.49	0.84	15	empty
2	62	0.40	0.80	20	empty
3	52	0.30	0.76	12	empty

Modifications

Observed in the structure: 2 modified (engineered).

Compared structures

1TFF · Structure of Otubain-2 · the same entry in another collection · chain A against A, TM-score 1.00
Q96DC9 · AlphaFold monomer V2.0 prediction for ubiquitin thioesterase OTUB2 (Q96DC9) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96DC9
Elsewhere: RCSB PDB 1TFF · PDBe 1TFF · UniProt Q96DC9

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