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Crystal structure of human endonuclease VIII-like 1 (NEIL1)

Analyse Crystal structure of human endonuclease VIII-like 1 (NEIL1) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1TDH
Type: protein
Length: 284 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nei endonuclease VIII-like 1
UniProt: Q96FI4
Pockets: 2 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nei endonuclease VIII-like 1	protein	284	31% helix, 23% strand	Q96FI4

Ligands and binding sites

TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	255	0.57	0.78	22	empty
2	70	0.28	0.73	15	TRS

Compared structures

1TDH · Crystal structure of human endonuclease VIII-like 1 (NEIL1) · the same entry in another collection · chain A against A, TM-score 1.00
Q96FI4 · AlphaFold monomer V2.0 prediction for endonuclease 8-like 1 (Q96FI4) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96FI4
Elsewhere: RCSB PDB 1TDH · PDBe 1TDH · UniProt Q96FI4

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