UniProt Q96FI4
Endonuclease 8-like 1 (Q96FI4)
Endonuclease 8-like 1 (UniProt Q96FI4), EC 3.2.2.-, 4.2.99.18: 52 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 257 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q96FI4
- Protein
- Endonuclease 8-like 1
- EC
- 3.2.2.-, 4.2.99.18
- Experimental structures
- 52
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 257 · 21 records with a druggable one
Structures
53 records of Q96FI4 in the MolNFT archive: 52 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1TDH | Crystal structure of human endonuclease VIII-like 1 (NEIL1) | x-ray diffraction | A | — | — |
| 1TDH | Crystal structure of human endonuclease VIII-like 1 (NEIL1) | x-ray diffraction | A | — | — |
| 4NRV | Crystal Structure of non-edited human NEIL1 | x-ray diffraction | A | — | — |
| 4NRV | Crystal structure of non-edited human NEIL1 | x-ray diffraction | A | — | — |
| 5ITQ | Crystal Structure of Human NEIL1, Free Protein | x-ray diffraction | A | — | — |
| 5ITQ | Crystal structure of human NEIL1, free protein | x-ray diffraction | A | — | — |
| 5ITR | Crystal Structure of Human NEIL1(P2G) bound to duplex DNA containing THF | x-ray diffraction | A, B, C | — | — |
| 5ITR | Crystal structure of human NEIL1(P2G) bound to duplex DNA containing thf | x-ray diffraction | A, B, C | — | — |
| 5ITT | Crystal Structure of Human NEIL1 bound to duplex DNA containing THF | x-ray diffraction | A, B, C | — | 12 (best 0.71) |
| 5ITT | Crystal structure of human NEIL1 bound to duplex DNA containing thf | x-ray diffraction | A, B, C | — | — |
| 5ITU | Crystal Structure of Human NEIL1(242K) bound to duplex DNA containing THF | x-ray diffraction | A, B, C | — | — |
| 5ITU | Crystal structure of human NEIL1(242K) bound to duplex DNA containing thf | x-ray diffraction | A, B, C | — | — |
| 5ITX | Crystal Structure of Human NEIL1(P2G R242K) bound to duplex DNA containing Thymine Glycol | x-ray diffraction | A, B, E | — | 13 (best 0.72) |
| 5ITX | Crystal structure of human NEIL1(P2G R242K) bound to duplex DNA containing thymine glycol | x-ray diffraction | A, B, E | — | — |
| 5ITY | Crystal Structure of Human NEIL1(P2G) bound to duplex DNA containing Thymine Glycol | x-ray diffraction | A, B, C | — | 14 (best 0.72) |
| 5ITY | Crystal structure of human NEIL1(P2G) bound to duplex DNA containing thymine glycol | x-ray diffraction | A, B, C | — | — |
| 6LWA | Crystal structure of human NEIL1(P2G, E3Q, K242) bound to duplex DNA containing 5-hydroxyuracil… | x-ray diffraction | A, D, G | — | 15 (best 0.71) |
| 6LWA | Crystal structure of human NEIL1(P2G, E3Q, K242) bound to duplex DNA containing 5-hydroxyuracil… | x-ray diffraction | A, D, G | — | — |
| 6LWB | Crystal structure of human NEIL1(P2G, E3Q, R242) bound to duplex DNA containing 5-hydroxyuracil… | x-ray diffraction | A, D, G | — | 15 (best 0.72) |
| 6LWB | Crystal structure of human NEIL1(P2G, E3Q, R242) bound to duplex DNA containing 5-hydroxyuracil… | x-ray diffraction | A, D, G | — | — |
| 6LWC | Crystal structure of human NEIL1(P2G, E3Q, K242) bound to duplex DNA containing… | x-ray diffraction | A, D | — | 8 (best 0.72) |
| 6LWC | Crystal structure of human NEIL1(P2G, E3Q, K242) bound to duplex DNA containing… | x-ray diffraction | A, D | — | — |
| 6LWD | Crystal structure of human NEIL1(P2G, E3Q, R242) bound to duplex DNA containing… | x-ray diffraction | A, D, G | — | 15 (best 0.72) |
| 6LWD | Crystal structure of human NEIL1(P2G, E3Q, R242) bound to duplex DNA containing… | x-ray diffraction | A, D, G | — | — |
| 6LWF | Crystal structure of human NEIL1(P2G, E3Q, K242) bound to duplex DNA containing guanidinohydantoin… | x-ray diffraction | A, D | — | 8 (best 0.69) |
| 6LWF | Crystal structure of human NEIL1(P2G, E3Q, K242) bound to duplex DNA containing guanidinohydantoin… | x-ray diffraction | A, D | — | — |
| 6LWG | Crystal structure of human NEIL1(P2G, E3Q, R242) bound to duplex DNA containing guanidinohydantoin… | x-ray diffraction | A, D, G | — | 15 (best 0.73) |
| 6LWG | Crystal structure of human NEIL1(P2G, E3Q, R242) bound to duplex DNA containing guanidinohydantoin… | x-ray diffraction | A, D, G | — | — |
| 6LWH | Crystal structure of human NEIL1(P2G, E3Q, K242) bound to duplex DNA containing dihydrothymine (DHT) | x-ray diffraction | A, D, G | — | 15 (best 0.72) |
| 6LWH | Crystal structure of human NEIL1(P2G, E3Q, K242) bound to duplex DNA containing dihydrothymine (dht) | x-ray diffraction | A, D, G | — | — |
| 6LWI | Crystal structure of human NEIL1(P2G, E3Q, R242) bound to duplex DNA containing dihydrothymine (DHT) | x-ray diffraction | A, D, G | — | 15 (best 0.74) |
| 6LWI | Crystal structure of human NEIL1(P2G, E3Q, R242) bound to duplex DNA containing dihydrothymine (dht) | x-ray diffraction | A, D, G | — | — |
| 6LWJ | Crystal structure of human NEIL1(P2G, E3Q, K242) bound to duplex DNA containing dihydrouracil (DHU) | x-ray diffraction | A, D, G | — | 14 (best 0.72) |
| 6LWJ | Crystal structure of human NEIL1(P2G, E3Q, K242) bound to duplex DNA containing dihydrouracil (dhu) | x-ray diffraction | A, D, G | — | — |
| 6LWK | Crystal structure of human NEIL1(P2G, E3Q, R242) bound to duplex DNA containing dihydrouracil (DHU) | x-ray diffraction | A, D, G | — | — |
| 6LWK | Crystal structure of human NEIL1(P2G, E3Q, R242) bound to duplex DNA containing dihydrouracil (dhu) | x-ray diffraction | A, D, G | — | — |
| 6LWL | Crystal structure of human NEIL1(R242) bound to duplex DNA containing… | x-ray diffraction | A, D, G | — | 15 (best 0.73) |
| 6LWL | Crystal structure of human NEIL1(R242) bound to duplex DNA containing… | x-ray diffraction | A, D, G | — | — |
| 6LWM | Crystal structure of human NEIL1(K242) bound to duplex DNA containing… | x-ray diffraction | A, D, G | — | 15 (best 0.72) |
| 6LWM | Crystal structure of human NEIL1(K242) bound to duplex DNA containing… | x-ray diffraction | A, D, G | — | — |
| 6LWN | Crystal structure of human NEIL1(R242, G249P) bound to duplex DNA containing… | x-ray diffraction | A, D, G | — | 13 (best 0.69) |
| 6LWN | Crystal structure of human NEIL1(R242, G249P) bound to duplex DNA containing… | x-ray diffraction | A, D, G | — | — |
| 6LWO | Crystal structure of human NEIL1(R242, Y244H) bound to duplex DNA containing… | x-ray diffraction | A, D, G | — | 15 (best 0.72) |
| 6LWO | Crystal structure of human NEIL1(R242, Y244H) bound to duplex DNA containing… | x-ray diffraction | A, D, G | — | — |
| 6LWP | Crystal structure of human NEIL1(R242, Y244R) bound to duplex DNA containing… | x-ray diffraction | A, D, G | — | 15 (best 0.70) |
| 6LWP | Crystal structure of human NEIL1(R242, Y244R) bound to duplex DNA containing… | x-ray diffraction | A, D, G | — | — |
| 6LWQ | Crystal structure of human NEIL1(R242) bound to duplex DNA containing a C:T mismatch | x-ray diffraction | A, D, G | — | 12 (best 0.72) |
| 6LWQ | Crystal structure of human NEIL1(R242) bound to duplex DNA containing a C:T mismatch | x-ray diffraction | A, D, G | — | — |
| 6LWR | Crystal structure of human NEIL1(K242) bound to duplex DNA containing a cleaved C:T mismatch | x-ray diffraction | A, E | — | 7 (best 0.69) |
| 6LWR | Crystal structure of human NEIL1(K242) bound to duplex DNA containing a cleaved C:T mismatch | x-ray diffraction | A, E | — | — |
| 7TMX | Structure of Mouse Importin alpha NEIL1 NLS Peptide Complex | x-ray diffraction | A, B | — | — |
| 8FTJ | Crystal structure of human NEIL1 (P2G (242K) C(delta)100) glycosylase bound to DNA duplex… | x-ray diffraction | A | SO4 | 4 (best 0.61) |
| Q96FI4 | AlphaFold monomer V2.0 prediction for endonuclease 8-like 1 (Q96FI4) | predicted | A | — | 2 (best 0.73) |
Ligands
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 6LWR chain E against the predicted model Q96FI4: TM-score 0.99, RMSD 0.57 Å
- 6LWR chain E against the predicted model Q96FI4: TM-score 0.99, RMSD 0.57 Å
- 6LWQ chain G against the predicted model Q96FI4: TM-score 0.99, RMSD 0.59 Å
- 6LWQ chain G against the predicted model Q96FI4: TM-score 0.99, RMSD 0.59 Å
- 6LWP chain G against the predicted model Q96FI4: TM-score 0.99, RMSD 0.61 Å
- 6LWP chain G against the predicted model Q96FI4: TM-score 0.99, RMSD 0.61 Å
- 6LWO chain D against the predicted model Q96FI4: TM-score 0.99, RMSD 0.67 Å
- 6LWO chain D against the predicted model Q96FI4: TM-score 0.99, RMSD 0.67 Å
- 6LWN chain G against the predicted model Q96FI4: TM-score 0.99, RMSD 0.65 Å
- 6LWN chain G against the predicted model Q96FI4: TM-score 0.99, RMSD 0.65 Å
Elsewhere
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