Research workbench
Structure of the trypsin-binding domain of bowman-birk type protease inhibitor and its interaction with trypsin
Analyse Structure of the trypsin-binding domain of bowman-birk type protease inhibitor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1TAB
- Type
- protein
- Length
- 259 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Trypsin; Bowman-birk type proteinase inhibitor
- EC
- 3.4.21.4
- UniProt
- P00760, P01058
- Pockets
- 1 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Trypsin (EC 3.4.21.4) | protein | 223 | 9% helix, 35% strand | P00760 |
| I | Bowman-birk type proteinase inhibitor | protein | 36 | 0% helix, 19% strand | P01058 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 149 | 0.44 | 0.76 | 27 | empty |
Interfaces
1 interface between chains.
- E–I · 711 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 1TAB · Structure of the trypsin-binding domain of bowman-birk type protease inhibitor and its… · the same entry in another collection · chain E against E, TM-score 1.00
- P01058 · AlphaFold monomer V2.0 prediction for bowman-birk type proteinase inhibitor (P01058) · a predicted model of the same protein · chain I against A, TM-score 0.55
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00760
- Every structure of UniProt P01058
- Elsewhere: RCSB PDB 1TAB · PDBe 1TAB · UniProt P00760 · UniProt P01058
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