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Use of sequence duplication to engineer a ligand-triggered long- distance molecular switch in T4 lysozyme

Analyse Use of sequence duplication to engineer a ligand-triggered long- distance… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1T97
Type: protein
Length: 338 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lysozyme
EC: 3.2.1.17
UniProt: P00720
Pockets: 5 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 61% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lysozyme (EC 3.2.1.17)	protein	165	61% helix, 8% strand	P00720
B	Lysozyme (EC 3.2.1.17)	protein	173	61% helix, 8% strand	P00720

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	218	0.81	0.94	31	empty
2	228	0.49	0.75	30	empty
3	230	0.47	0.73	28	empty
4	70	0.39	0.78	18	empty
5	58	0.29	0.74	17	empty

Interfaces

1 interface between chains.

A–B · 903 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

1T97 · Use of sequence duplication to engineer a ligand-triggered long-distance molecular switch… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00720
Elsewhere: RCSB PDB 1T97 · PDBe 1T97 · UniProt P00720

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