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Crystal structure of the androgen receptor ligand binding domain in complex with 5-alpha dihydrotestosterone

Analyse Crystal structure of the androgen receptor ligand binding domain in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1T7T
Type: protein
Length: 250 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Androgen receptor
UniProt: O97775
Ligands: DHT
Pockets: 2 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 68% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Androgen receptor	protein	250	68% helix, 5% strand	O97775

Ligands and binding sites

DHT · 5-alpha-dihydrotestosterone · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	156	0.83	0.98	21	DHT
2	147	0.62	0.85	27	empty

Compared structures

1T7T · Crystal structure of the androgen receptor ligand binding domain in complex with 5-alpha… · the same entry in another collection · chain A against A, TM-score 1.00
O97775 · AlphaFold monomer V2.0 prediction for androgen receptor (O97775) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O97775
Elsewhere: RCSB PDB 1T7T · PDBe 1T7T · UniProt O97775

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