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Crystal structure of the N-terminal domain of human UAP56

Analyse Crystal structure of the N-terminal domain of human UAP56 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1T6N
Type: protein
Length: 414 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable ATP-dependent RNA helicase
UniProt: Q13838
Pockets: 2 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Probable ATP-dependent RNA helicase	protein	207	42% helix, 15% strand	Q13838

Ligands and binding sites

FLC · Citrate anion · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	627	0.72	0.80	83	FLC
2	62	0.26	0.72	18	FLC

Interfaces

1 interface between chains.

A–B · 780 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

1T6N · Crystal structure of the N-terminal domain of human UAP56 · the same entry in another collection · chain A against A, TM-score 1.00
Q13838 · AlphaFold monomer V2.0 prediction for spliceosome RNA helicase DDX39B (Q13838) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13838
Elsewhere: RCSB PDB 1T6N · PDBe 1T6N · UniProt Q13838

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