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Structural basis for the autoinhibition and sti-571 inhibition of C- kit tyrosine kinase

Analyse Structural basis for the autoinhibition and sti-571 inhibition of C- kit… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1T45
Type: protein
Length: 331 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Homo sapiens V-kit hardy-zuckerman 4 feline sarcoma viral oncogene homolog
EC: 2.7.1.112
UniProt: P10721
Pockets: 3 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Homo sapiens V-kit hardy-zuckerman 4 feline sarcoma viral oncogene homolog (EC 2.7.1.112)	protein	331	40% helix, 18% strand	P10721

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	129	0.65	0.87	31	empty
2	231	0.58	0.79	23	empty
3	83	0.37	0.76	21	empty

Compared structures

1T45 · Structural basis for the autoinhibition and sti-571 inhibition of C-kit tyrosine kinase · the same entry in another collection · chain A against A, TM-score 1.00
P10721 · AlphaFold monomer V2.0 prediction for MAST/STEM cell growth factor receptor kit (P10721) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10721
Elsewhere: RCSB PDB 1T45 · PDBe 1T45 · UniProt P10721

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