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High resolution crystal structure of the intact pro-kumamolisin, a sedolisin type proteinase (previously called kumamolysin or kscp)

Analyse High resolution crystal structure of the intact pro-kumamolisin, a sedolisin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1T1E
Type: protein
Length: 534 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Kumamolisin
UniProt: Q8RR56
Ligands: CA
Pockets: 8 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 28% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Kumamolisin	protein	534	28% helix, 25% strand	Q8RR56

Ligands and binding sites

CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	315	0.59	0.78	39	empty
2	93	0.37	0.75	22	empty
3	94	0.36	0.75	19	empty
4	81	0.34	0.75	16	empty
5	68	0.34	0.76	15	empty

Compared structures

1T1E · High Resolution Crystal Structure of the Intact Pro-Kumamolisin, a Sedolisin Type… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8RR56
Elsewhere: RCSB PDB 1T1E · PDBe 1T1E · UniProt Q8RR56

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