Research workbench
Crystal structure of lush from drosophila melanogaster: apo protein
Analyse Crystal structure of lush from drosophila melanogaster: apo protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1T14
- Type
- protein
- Length
- 248 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lush
- UniProt
- O02372
- Pockets
- 5 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 65% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Lush | protein | 124 | 65% helix, 2% strand | O02372 |
Ligands and binding sites
- ACT · Acetate ion · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 206 | 0.81 | 0.94 | 28 | ACT |
| 2 | 196 | 0.79 | 0.93 | 31 | ACT |
| 3 | 175 | 0.54 | 0.80 | 33 | empty |
| 4 | 61 | 0.35 | 0.77 | 11 | empty |
| 5 | 68 | 0.35 | 0.76 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 714 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1T14 · Crystal structure of LUSH from Drosophila melanogaster: apo protein · the same entry in another collection · chain A against A, TM-score 1.00
- O02372 · AlphaFold monomer V2.0 prediction for general odorant-binding protein lush (O02372) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O02372
- Elsewhere: RCSB PDB 1T14 · PDBe 1T14 · UniProt O02372
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