Structural basis of icam recognition by integrin ALPAHLBETA2 revealed in the complex structure of binding domains of icam-3 and ALPHALBETA2 at 1.65 a

Structure

x-ray diffraction · 2 distinct chains · 25% helix, 37% strand (DSSP).

Ligands and binding sites

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains B
• MG · Magnesium ion · metal · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 647 Ų buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide, 2 glycan (disulfide, N-glycosylation).

Compared structures

• 1T0P · Structural Basis of ICAM recognition by integrin alpahLbeta2 revealed in the complex… · the same entry in another collection · chain A against A, TM-score 1.00
• P32942 · AlphaFold monomer V2.0 prediction for intercellular adhesion molecule 3 (P32942) · a predicted model of the same protein · chain B against A, TM-score 0.95
• P20701 · AlphaFold monomer V2.0 prediction for integrin alpha-L (P20701) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P20701
• Every structure of UniProt P32942
• Elsewhere: RCSB PDB 1T0P · PDBe 1T0P · UniProt P20701 · UniProt P32942