Research workbench
Vinculin complexed with the VBS1 helix from talin
Analyse Vinculin complexed with the VBS1 helix from talin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1T01
- Type
- protein
- Length
- 279 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Unnamed protein product; Talin 1
- UniProt
- P12003, P26039
- Pockets
- 2 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 80% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Unnamed protein product | protein | 255 | 79% helix, 1% strand | P12003 |
| B | Talin 1 | protein | 24 | 88% helix, 0% strand | P26039 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 144 | 0.47 | 0.77 | 18 | empty |
| 2 | 53 | 0.28 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1164 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 1T01 · Vinculin complexed with the VBS1 helix from talin · the same entry in another collection · chain A against A, TM-score 1.00
- P12003 · AlphaFold monomer V2.0 prediction for vinculin (P12003) · a predicted model of the same protein · chain A against A, TM-score 0.89
- P26039 · AlphaFold monomer V2.0 prediction for talin-1 (P26039) · a predicted model of the same protein · chain B against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12003
- Every structure of UniProt P26039
- Elsewhere: RCSB PDB 1T01 · PDBe 1T01 · UniProt P12003 · UniProt P26039
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.