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Core-streptavidin mutant W108F at pH 7.0

Analyse Core-streptavidin mutant W108F at pH 7.0 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1SWL
Type: protein
Length: 455 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Core-streptavidin
UniProt: P22629
Pockets: 4 · best druggability 0.68

Structure

x-ray diffraction · 3 distinct chains · 6% helix, 58% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Core-streptavidin	protein	119	5% helix, 57% strand	P22629
B	Core-streptavidin	protein	114	8% helix, 57% strand	P22629
C, D	Core-streptavidin	protein	111	5% helix, 59% strand	P22629

Pockets

4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	292	0.68	0.83	45	empty
2	312	0.62	0.79	36	empty
3	345	0.61	0.78	40	empty
4	275	0.60	0.79	38	empty

Interfaces

6 interfaces between chains.

C–D · 1652 Å² buried · 20 hydrogen bonds · protein-protein
A–B · 1636 Å² buried · 22 hydrogen bonds · protein-protein
A–D · 487 Å² buried · 2 hydrogen bonds · protein-protein
B–C · 408 Å² buried · 3 hydrogen bonds · protein-protein
A–C · 196 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

1SWL · Core-streptavidin mutant W108F at pH 7.0 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22629
Elsewhere: RCSB PDB 1SWL · PDBe 1SWL · UniProt P22629

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