Research workbench
MP1-P14 complex
Analyse MP1-P14 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1SKO
- Type
- protein
- Length
- 235 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase kinase 1 interacting protein 1; Late ENDOSOMAL/LYSOSOMAL…
- UniProt
- Q9UHA4, Q9JHS3
- Pockets
- 2 · best druggability 0.42
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase kinase 1 interacting protein 1 | protein | 119 | 41% helix, 31% strand | Q9UHA4 |
| B | Late ENDOSOMAL/LYSOSOMAL MP1 interacting protein | protein | 116 | 34% helix, 31% strand | Q9JHS3 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 117 | 0.42 | 0.76 | 22 | empty |
| 2 | 60 | 0.30 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1256 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 1SKO · MP1-p14 Complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UHA4 · AlphaFold monomer V2.0 prediction for ragulator complex protein LAMTOR3 (Q9UHA4) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9JHS3 · AlphaFold monomer V2.0 prediction for ragulator complex protein LAMTOR2 (Q9JHS3) · a predicted model of the same protein · chain B against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UHA4
- Every structure of UniProt Q9JHS3
- Elsewhere: RCSB PDB 1SKO · PDBe 1SKO · UniProt Q9UHA4 · UniProt Q9JHS3
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