Research workbench
The crystal structure of hgf beta-chain in complex with the sema domain of the met receptor.
Analyse The crystal structure of hgf beta-chain in complex with the sema domain of the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1SHY
- Type
- protein
- Length
- 727 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hepatocyte growth factor; Hepatocyte growth factor receptor
- UniProt
- P14210, P08581
- Pockets
- 10 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hepatocyte growth factor | protein | 228 | 11% helix, 36% strand | P14210 |
| B | Hepatocyte growth factor receptor | protein | 499 | 8% helix, 41% strand | P08581 |
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 805 | 0.74 | 0.79 | 59 | empty |
| 2 | 783 | 0.69 | 0.76 | 56 | empty |
| 3 | 215 | 0.67 | 0.85 | 51 | empty |
| 4 | 166 | 0.57 | 0.82 | 31 | empty |
| 5 | 107 | 0.48 | 0.80 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 934 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 disulfide (disulfide).
Compared structures
- 1SHY · The Crystal Structure of HGF beta-chain in Complex with the Sema Domain of the Met… · the same entry in another collection · chain A against A, TM-score 1.00
- P08581 · AlphaFold monomer V2.0 prediction for hepatocyte growth factor receptor (P08581) · a predicted model of the same protein · chain B against A, TM-score 0.95
- P14210 · AlphaFold monomer V2.0 prediction for hepatocyte growth factor (P14210) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14210
- Every structure of UniProt P08581
- Elsewhere: RCSB PDB 1SHY · PDBe 1SHY · UniProt P14210 · UniProt P08581
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