UniProt P14210
Hepatocyte growth factor (P14210)
Hepatocyte growth factor (UniProt P14210): 59 experimental structures on GenesisL1, 5 ligands bound, 4 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P14210
- Protein
- Hepatocyte growth factor
- Experimental structures
- 59
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 4 · 1 record with a druggable one
Structures
59 records of P14210 in the MolNFT archive: 59 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BHT | NK1 fragment of human hepatocyte growth factor | x-ray diffraction | A, B | — | — |
| 1BHT | NK1 fragment of human hepatocyte growth factor | x-ray diffraction | A, B | — | — |
| 1GMN | Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable… | x-ray diffraction | A, B | — | — |
| 1GMN | Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable… | x-ray diffraction | A, B | — | — |
| 1GMO | Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1GMO | Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1GP9 | A New Crystal Form of the Nk1 Splice Variant of Hgf/Sf Demonstrates Extensive Hinge Movement and… | x-ray diffraction | A, B, C, D | — | — |
| 1GP9 | A new crystal form of the NK1 splice variant of HGF/SF demonstrates extensive hinge movement and… | x-ray diffraction | A, B, C, D | — | — |
| 1NK1 | NK1 fragment of human hepatocyte growth FACTOR/SCATTER factor (HGF/SF) at 2.5 ångström resolution | x-ray diffraction | A, B | — | — |
| 1NK1 | NK1 fragment of human hepatocyte growth FACTOR/SCATTER factor (HGF/SF) at 2.5 ångström resolution | x-ray diffraction | A, B | — | — |
| 1SHY | The Crystal Structure of HGF beta-chain in Complex with the Sema Domain of the Met Receptor. | x-ray diffraction | A | — | — |
| 1SHY | The crystal structure of hgf beta-chain in complex with the sema domain of the met receptor. | x-ray diffraction | A | — | — |
| 1SI5 | Protease-like domain from 2-chain hepatocyte growth factor | x-ray diffraction | H | — | — |
| 1SI5 | Protease-like domain from 2-chain hepatocyte growth factor | x-ray diffraction | H | — | — |
| 2HGF | Hairpin loop containing domain of hepatocyte growth factor, NMR, minimized average structure | solution nmr | A | — | — |
| 2HGF | Hairpin loop containing domain of hepatocyte growth factor, NMR, minimized average structure | solution nmr | A | — | — |
| 2QJ2 | A Mechanistic Basis for Converting a Receptor Tyrosine Kinase Agonist to an Antagonist | x-ray diffraction | A, B | — | — |
| 2QJ2 | A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist | x-ray diffraction | A, B | — | — |
| 3HMS | Crystal Crystal structure of the N-terminal fragment (28-126) of the human hepatocyte growth… | x-ray diffraction | A | — | — |
| 3HMS | Crystal crystal structure of the N-terminal fragment (28-126) of the human hepatocyte growth… | x-ray diffraction | A | — | — |
| 3HMT | Crystal structure of the N-terminal fragment (28-126) of the human hepatocyte growth factor/scatter… | x-ray diffraction | A, B | — | — |
| 3HMT | Crystal structure of the N-terminal fragment (28-126) of the human hepatocyte growth FACTOR/SCATTER… | x-ray diffraction | A, B | — | — |
| 3HN4 | Crystal structure of the NK2 fragment (28-289) of human hepatocyte growth factor/scatter factor | x-ray diffraction | A | — | — |
| 3HN4 | Crystal structure of the NK2 fragment (28-289) of human hepatocyte growth FACTOR/SCATTER factor | x-ray diffraction | A | — | — |
| 3MKP | Crystal structure of 1K1 mutant of Hepatocyte Growth Factor/Scatter Factor fragment NK1 in complex… | x-ray diffraction | A, B, C, D | — | — |
| 3MKP | Crystal structure of 1K1 mutant of hepatocyte growth FACTOR/SCATTER factor fragment NK1 in complex… | x-ray diffraction | A, B, C, D | — | — |
| 3SP8 | Crystal structure of NK2 in complex with fractionated Heparin DP10 | x-ray diffraction | A, B | — | — |
| 3SP8 | Crystal structure of NK2 in complex with fractionated heparin DP10 | x-ray diffraction | A, B | — | — |
| 4D3C | Crystal structure of the NK1 domain of HGF in complex with anti-HGF monoclonal antibody SFN68. | x-ray diffraction | A | — | — |
| 4D3C | Crystal structure of the NK1 domain of hgf in complex with anti-hgf monoclonal antibody SFN68. | x-ray diffraction | A | — | — |
| 4K3J | Crystal structure of Onartuzumab Fab in complex with MET and HGF-beta | x-ray diffraction | A | — | — |
| 4K3J | Crystal structure of onartuzumab Fab in complex with met and hgf-beta | x-ray diffraction | A | — | — |
| 4O3T | Zymogen HGF-beta/MET with Zymogen Activator Peptide ZAP.14 | x-ray diffraction | A | — | — |
| 4O3T | Zymogen hgf-BETA/MET with zymogen activator peptide ZAP.14 | x-ray diffraction | A | — | — |
| 4O3U | Zymogen HGF-beta/MET with Zymogen Activator Peptide ZAP2.3 | x-ray diffraction | A | — | — |
| 4O3U | Zymogen hgf-BETA/MET with zymogen activator peptide ZAP2.3 | x-ray diffraction | A | — | — |
| 5COE | The structure of the NK1 fragment of HGF/SF complexed with hepes | x-ray diffraction | A, B | — | — |
| 5CP9 | The structure of the NK1 fragment of HGF/SF complexed with MB605 | x-ray diffraction | A, B | 6O5 | — |
| 5CP9 | The structure of the NK1 fragment of HGF/SF complexed with MB605 | x-ray diffraction | A, B | — | — |
| 5CS1 | The structure of the NK1 fragment of HGF/SF | x-ray diffraction | A, B | — | — |
| 5CS3 | The structure of the NK1 fragment of HGF/SF complexed with (H)EPPS | x-ray diffraction | A, B | EP1 | — |
| 5CS3 | The structure of the NK1 fragment of HGF/SF complexed with (H)EPPS | x-ray diffraction | A, B | — | — |
| 5CS5 | The structure of the NK1 fragment of HGF/SF complexed with pipes | x-ray diffraction | A, B | — | — |
| 5CS9 | The structure of the NK1 fragment of HGF/SF complexed with MES | x-ray diffraction | A, B | — | 4 (best 0.69) |
| 5CS9 | The structure of the NK1 fragment of HGF/SF complexed with mes | x-ray diffraction | A, B | — | — |
| 5CSQ | The structure of the NK1 fragment of HGF/SF complexed with mops | x-ray diffraction | A, B | — | — |
| 5CT1 | The structure of the NK1 fragment of HGF/SF complexed with ches | x-ray diffraction | A, B | — | — |
| 5CT2 | The structure of the NK1 fragment of HGF/SF complexed with caps | x-ray diffraction | A, B | — | — |
| 5CT3 | The structure of the NK1 fragment of HGF/SF complexed with 2FA | x-ray diffraction | A, B | 54O | — |
| 5CT3 | The structure of the NK1 fragment of HGF/SF complexed with 2FA | x-ray diffraction | A, B | — | — |
| 6LZ9 | T8E4 antibody Fab complexed with the active form of hgf | x-ray diffraction | A, B | — | — |
| 7MO7 | Cryo-EM structure of 2:2 C-MET/HGF holo-complex | electron microscopy | D, A | SGN, IDS | — |
| 7MO8 | Cryo-EM structure of 1:1 C-met I/HGF I complex after focused 3D refinement of holo-complex | electron microscopy | A | SGN, IDS | — |
| 7MO9 | Cryo-EM MAP of the C-met II/HGF I/HGF II (K4 and sph) sub-complex | electron microscopy | A, D | IDS, SGN | — |
| 7MOA | Cryo-EM structure of the C-met II/HGF I complex bound with hgf II in a rigid conformation | electron microscopy | A, D | SGN, IDS | — |
| 7MOB | Cryo-EM structure of 2:2 C-MET/NK1 complex | electron microscopy | A, B | — | — |
| 7OCL | K1K1, a potent recombinant minimal hepatocyte growth FACTOR/SCATTER factor mimic | x-ray diffraction | A, B | — | — |
| 7OCM | K1K1H6, a potent recombinant minimal hepatocyte growth FACTOR/SCATTER factor mimic | x-ray diffraction | A | — | — |
| P14210 | AlphaFold monomer V2.0 prediction for hepatocyte growth factor (P14210) | — | — | — |
Ligands
- IDS · 2-O-sulfo-alpha-L-idopyranuronic acid · in 4 records
- SGN · 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose · in 4 records
- 54O · 3-hydroxypropane-1-sulfonic acid · in 1 record
- 6O5 · 3-(furan-2-yl)propanoic acid · in 1 record
- EP1 · 3-[4-(2-hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid · in 1 record
Elsewhere
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