Research workbench
Crystal structure of a cold adapted subtilisin-like serine proteinase
Analyse Crystal structure of a cold adapted subtilisin-like serine proteinase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1SH7
- Type
- protein
- Length
- 555 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Extracellular subtilisin-like serine proteinase
- EC
- 3.4.21.-
- UniProt
- Q8GB52
- Ligands
- PMS, CA
- Pockets
- 2 · best druggability 0.36
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Extracellular subtilisin-like serine proteinase (EC 3.4.21.-) | protein | 281 | 26% helix, 22% strand | Q8GB52 |
| B | Extracellular subtilisin-like serine proteinase (EC 3.4.21.-) | protein | 274 | 27% helix, 23% strand | Q8GB52 |
Ligands and binding sites
- PMS · phenylmethanesulfonic acid · ligand · 2 copies · chains A, B
- CA · Calcium ion · metal · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 92 | 0.36 | 0.75 | 28 | PMS |
| 2 | 105 | 0.35 | 0.74 | 32 | PMS |
Modifications
Observed in the structure: 5 disulfide, 2 covalent (disulfide, covalent ligand).
Compared structures
- 1SH7 · Crystal structure of a cold adapted subtilisin-like serine proteinase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8GB52
- Elsewhere: RCSB PDB 1SH7 · PDBe 1SH7 · UniProt Q8GB52
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