E. COLI uridine phosphorylase: 2'-deoxyuridine phosphate complex

Structure

x-ray diffraction · 3 distinct chains · 33% helix, 30% strand (DSSP).

Ligands and binding sites

• DUR · 2'-deoxyuridine · ligand · 25 copies · chains A, a, B, b, C, c, D, d, E, e, F, R, G, P, H, h, I, i, J, j, K, k, L, l, M, m, N, Q, O, o
• V7O · Meta vanadate · ligand · 20 copies · chains A, B, C, a, b, c, D, E, F, d, e, R, G, H, I, P, h, i, J, K, L, j, k, l, M, N, O, m, Q, o
• K · Potassium ion · metal · 15 copies · chains A, a, B, b, C, c, D, d, E, e, F, R, G, P, H, h, I, i, J, j, K, k, L, l, M, m, N, Q, O, o
• PO4 · Phosphate ion · ion · 25 copies · chains A, a, B, b, C, c, D, d, E, e, F, R, G, P, H, h, I, i, J, j, K, k, L, l, M, m, N, Q, O, o

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Interfaces

75 interfaces between chains.

• H–h · 2098 Ų buried · 19 hydrogen bonds · protein-protein
• I–i · 2091 Ų buried · 19 hydrogen bonds · protein-protein
• J–j · 2091 Ų buried · 19 hydrogen bonds · protein-protein
• G–P · 2089 Ų buried · 21 hydrogen bonds · protein-protein
• B–b · 2088 Ų buried · 18 hydrogen bonds · protein-protein

Compared structures

• 1RXS · E. coli uridine phosphorylase: 2'-deoxyuridine phosphate complex · the same entry in another collection · chain F against F, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P12758
• Elsewhere: RCSB PDB 1RXS · PDBe 1RXS · UniProt P12758