Research workbench
Crystal structure of arthrobacter aurescens chondroitin ac lyase in complex with chondroitin tetrasaccharide
Analyse Crystal structure of arthrobacter aurescens chondroitin ac lyase in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1RWG
- Type
- protein
- Length
- 754 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chondroitin ac lyase
- EC
- 4.2.2.5
- UniProt
- P84141
- Ligands
- ASG, GCT, GAD, NA, PO4
- Pockets
- 6 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chondroitin ac lyase (EC 4.2.2.5) | protein | 754 | 32% helix, 27% strand | P84141 |
Ligands and binding sites
- ASG · 2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose · ligand · 2 copies · chains A
- GCT · 2,6-anhydro-3-deoxy-L-xylo-hexonic acid · ligand · chains A
- GAD · 2,6-anhydro-3-deoxy-L-threo-hex-2-enonic acid · ligand · chains A
- NA · Sodium ion · metal · chains A
- PO4 · Phosphate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 896 | 0.75 | 0.78 | 79 | ASG, GCT, GAD, PO4 |
| 2 | 73 | 0.47 | 0.83 | 17 | empty |
| 3 | 51 | 0.36 | 0.79 | 15 | empty |
| 4 | 51 | 0.35 | 0.79 | 16 | empty |
| 5 | 66 | 0.33 | 0.76 | 15 | empty |
Compared structures
- 1RWG · Crystal structure of Arthrobacter aurescens chondroitin AC lyase in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P84141
- Elsewhere: RCSB PDB 1RWG · PDBe 1RWG · UniProt P84141
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.