Research workbench
Human vinculin head (1-258) in complex with TALIN'S vinculin binding site 3 (residues 1944-1969)
Analyse Human vinculin head (1-258) in complex with TALIN'S vinculin binding site 3… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1RKC
- Type
- protein
- Length
- 284 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vinculin; Talin
- UniProt
- P18206, P54939
- Pockets
- 3 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vinculin | protein | 258 | 71% helix, 1% strand | P18206 |
| B | Talin | protein | 26 | 73% helix, 0% strand | P54939 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 201 | 0.59 | 0.81 | 18 | empty |
| 2 | 106 | 0.41 | 0.77 | 16 | empty |
| 3 | 77 | 0.33 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1251 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 1RKC · Human vinculin head (1-258) in complex with talin's vinculin binding site 3 (residues… · the same entry in another collection · chain A against A, TM-score 1.00
- P18206 · AlphaFold monomer V2.0 prediction for vinculin (P18206) · a predicted model of the same protein · chain A against A, TM-score 0.79
- P54939 · AlphaFold monomer V2.0 prediction for talin-1 (P54939) · a predicted model of the same protein · chain B against A, TM-score 0.67
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18206
- Every structure of UniProt P54939
- Elsewhere: RCSB PDB 1RKC · PDBe 1RKC · UniProt P18206 · UniProt P54939
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