Research workbench
Crystal structure of a soluble dimeric form of oxidised CLIC1
Analyse Crystal structure of a soluble dimeric form of oxidised CLIC1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1RK4
- Type
- protein
- Length
- 419 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chloride intracellular channel protein 1
- UniProt
- O00299
- Pockets
- 7 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 55% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chloride intracellular channel protein 1 | protein | 213 | 54% helix, 0% strand | O00299 |
| B | Chloride intracellular channel protein 1 | protein | 206 | 56% helix, 0% strand | O00299 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 186 | 0.67 | 0.86 | 37 | empty |
| 2 | 213 | 0.66 | 0.84 | 40 | empty |
| 3 | 53 | 0.45 | 0.84 | 21 | empty |
| 4 | 54 | 0.44 | 0.84 | 24 | empty |
| 5 | 142 | 0.43 | 0.75 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1157 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1RK4 · Crystal Structure of a Soluble Dimeric Form of Oxidised CLIC1 · the same entry in another collection · chain A against A, TM-score 1.00
- O00299 · AlphaFold monomer V2.0 prediction for chloride intracellular channel protein 1 (O00299) · a predicted model of the same protein · chain A against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00299
- Elsewhere: RCSB PDB 1RK4 · PDBe 1RK4 · UniProt O00299
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