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Crystal structure of FLT3

Analyse Crystal structure of FLT3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1RJB
Type: protein
Length: 298 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fl cytokine receptor
EC: 2.7.1.112
UniProt: P36888
Pockets: 4 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fl cytokine receptor (EC 2.7.1.112)	protein	298	38% helix, 22% strand	P36888

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	154	0.53	0.80	20	empty
2	76	0.47	0.83	16	empty
3	93	0.40	0.77	23	empty
4	80	0.39	0.78	22	empty

Compared structures

1RJB · Crystal Structure of FLT3 · the same entry in another collection · chain A against A, TM-score 1.00
P36888 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein kinase FLT3 (P36888) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P36888
Elsewhere: RCSB PDB 1RJB · PDBe 1RJB · UniProt P36888

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