ARF1[DELTA1-17]-GDP in complex with a SEC7 domain carrying the mutation of the catalytic glutamate to lysine

Structure

x-ray diffraction · 2 distinct chains · 52% helix, 11% strand (DSSP).

Ligands and binding sites

• GDP · Guanosine-5'-diphosphate · ligand · chains A, E
• SO4 · Sulfate ion · ion · chains E
• SO3 · Sulfite ion · ion · chains A, E
• FMT · Formic acid · additive · 3 copies · chains A, E
• BME · Beta-mercaptoethanol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–E · 1545 Ų buried · 20 hydrogen bonds · protein-protein

Compared structures

• 1R8S · ARF1[DELTA1-17]-GDP in complex with a SEC7 domain carrying the mutation of the catalytic… · the same entry in another collection · chain A against A, TM-score 1.00
• Q99418 · AlphaFold monomer V2.0 prediction for cytohesin-2 (Q99418) · a predicted model of the same protein · chain E against A, TM-score 0.90
• P84080 · AlphaFold monomer V2.0 prediction for ADP-ribosylation factor 1 (P84080) · a predicted model of the same protein · chain A against A, TM-score 0.85

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P84080
• Every structure of UniProt Q99418
• Elsewhere: RCSB PDB 1R8S · PDBe 1R8S · UniProt P84080 · UniProt Q99418