Research workbench
Glycosyltransferase a in complex with 3-amino-acceptor analog inhibitor
Analyse Glycosyltransferase a in complex with 3-amino-acceptor analog inhibitor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1R7V
- Type
- protein
- Length
- 263 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycoprotein-fucosylgalactoside alpha-N- acetylgalactosaminyltransferase
- EC
- 2.4.1.40
- UniProt
- P16442
- Ligands
- AIG, FUC, HG
- Pockets
- 2 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glycoprotein-fucosylgalactoside alpha-N- acetylgalactosaminyltransferase (EC 2.4.1.40) | protein | 263 | 31% helix, 23% strand | P16442 |
Ligands and binding sites
- AIG · hexyl 3-amino-3-deoxy-beta-D-galactopyranoside · ligand · chains A
- FUC · alpha-L-fucopyranose · sugar · chains A
- HG · Mercury (II) ion · metal · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 273 | 0.57 | 0.77 | 31 | HG |
| 2 | 64 | 0.27 | 0.72 | 15 | FUC |
Compared structures
- 1R7V · Glycosyltransferase A in complex with 3-amino-acceptor analog inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
- P16442 · AlphaFold monomer V2.0 prediction for histo-blood group abo system transferase (P16442) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16442
- Elsewhere: RCSB PDB 1R7V · PDBe 1R7V · UniProt P16442
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