GL1X · GenesisL1 explorer

Research workbench

Glycosyltransferase B in complex with 3-deoxy-acceptor analog inhibitor

Analyse Glycosyltransferase B in complex with 3-deoxy-acceptor analog inhibitor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1R7U
Type
protein
Length
264 residues
Chains
1
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Glycoprotein-fucosylgalactoside alpha- galactosyltransferase
EC
2.4.1.37
UniProt
P16442
Ligands
DLG, FUC, HG
Pockets
1 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 22% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AGlycoprotein-fucosylgalactoside alpha- galactosyltransferase (EC 2.4.1.37)protein26430% helix, 22% strandP16442

Ligands and binding sites

  • DLG · hexyl 3-deoxy-beta-D-galactopyranoside · ligand · chains A
  • FUC · alpha-L-fucopyranose · sugar · chains A
  • HG · Mercury (II) ion · metal · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
12750.560.7628HG

Compared structures

  • 1R7U · Glycosyltransferase B in complex with 3-deoxy-acceptor analog inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
  • P16442 · AlphaFold monomer V2.0 prediction for histo-blood group abo system transferase (P16442) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.