Research workbench
Crystal structure analysis of SUP35 complexed with gmppnp
Analyse Crystal structure analysis of SUP35 complexed with gmppnp in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1R5O
- Type
- protein
- Length
- 409 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic peptide chain release factor GTP- binding subunit
- UniProt
- O74718
- Ligands
- GNP
- Pockets
- 5 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 18% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic peptide chain release factor GTP- binding subunit | protein | 409 | 18% helix, 32% strand | O74718 |
Ligands and binding sites
- GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 432 | 0.63 | 0.77 | 45 | empty |
| 2 | 107 | 0.49 | 0.81 | 22 | empty |
| 3 | 79 | 0.44 | 0.81 | 16 | empty |
| 4 | 141 | 0.43 | 0.75 | 13 | empty |
| 5 | 54 | 0.24 | 0.72 | 16 | empty |
Compared structures
- 1R5O · crystal structure analysis of sup35 complexed with GMPPNP · the same entry in another collection · chain A against A, TM-score 1.00
- O74718 · AlphaFold monomer V2.0 prediction for eukaryotic peptide chain release factor GTP-binding… · a predicted model of the same protein · chain A against A, TM-score 0.52
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O74718
- Elsewhere: RCSB PDB 1R5O · PDBe 1R5O · UniProt O74718
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